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Brain Abnormalities in Newly Diagnosed Neuropsychiatric Lupus: Systematic MRI Approach and Correlation with Clinical and Laboratory Data in a Large Multicenter Cohort Autoimmun Rev 14:153-159, Sarbu, N.,et al, 2015 See this aricle in Pubmed Article Abstract We included 108 patients (mean 40.6 � 14.2 years; range 14-77), 91.7% women. The most frequent syndromes were headache (28.5%), cerebrovascular disease (15.5%), and cognitive dysfunction (11.4%). Brain abnormalities were found in 59.3%. SVD was the most common (55.6%), followed by LVD (13%) and inflammatory-like lesions (6.5%). The most frequent SVD findings were WMH (53.7%), atrophy (18.5%), microbleeds (13.7%) and lacunes (11.1%). Cerebrovascular syndrome correlated with LVD (p=0.001) and microbleeds (p=0.002), cognitive dysfunction with WMH (p=0.045) and myelopathy with inflammatory-like lesions (p=0.020). Low C4 and CH50 correlated with inflammatory-like lesions (p�0.001, 9=0.019) and lupus anticoagulant with WMH (p=0.018), microbleeds (p=0.002) and atrophy (p=0.008). Vascular disease is the hallmark of NPSLE. Certain syndromes and immunological patterns are prone to more extensive brain damage. MRI could provide significant clinical information and insights into the pathological substrate.

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(click to filter results - removes previous filter) brain atrophy cerebral infarction,subcortical cerebrovascular accident cognition dementia headache lacunar infarction lupus anticoagulant meningitis,aseptic meningitis,noninfectious microhemorrhage,intracerebral MRI,abnormal MRI,contrast enhanced MRI,negative myelopathy pleocytosis of cerebrospinal fluid psychosis seizure small vessel disease systemic lupus erythematosus systemic lupus erythematosus,neurologic complications with white matter disease

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